1. The relationship of the pathological change of the senile plagues with the abilities of learning and memory in the brain of AD model mice was considered. 随着年龄的增加，小鼠海马Aβ沉积明显加剧，在4.5个月AD模型鼠脑切片上已有β淀粉样蛋白斑块的形成，而6-8个月的AD鼠海马内Aβ沉积斑块数量明显增多，体积明显增大。