1. 脂质体介导的S10OA4反义寡核普酸能够抑制神经母细胞瘤LA一N一6和SK一N一SH细胞中5100A4 mRNA表达，抑制LA一6细胞体外侵袭能力、运动能力，同时下调两种细胞中MMP一2 mRNA的表达，因此，SIOOA4基因在神经母细胞瘤侵袭过程中发挥重要作用；其作用机制公尹左夕拳几澎廷萝脱，须土一学莎不旨丈中灵撇萝可能与增加肿瘤细胞运动能力，调节MMP一2基因表达有关。
There were no significant changes in MMP-2 mRNA levels in the sODN- and mODN- treated cells. Conclusion: S100A4 asODN is capable of significantly down-regulating S100A4 mRNA expression, and suppressing the invasive and motile abilities of neuroblastoma cells, with concomitant decrease of MMP-2 mRNA levels, so the biological activity of S100A4 gene on invasion of neuroblastoma cells may realize via stimulating the motility of tumor cells and influencing the expression of MMP-2 gene.